In 1948 – The University of California at Berkeley and the Atomic Energy Commission announced the artificial production of mesons using the 184-inch cyclotron at the university’s Radiation Laboratory.
In 1961 – Sputnik 9 successfully launched, carrying a human dummy and and the dog Chernushka. It completed 1 orbit and was successfully recovered upon return. Yes, the dog made it back unharmed.
In 2011 – Space Shuttle Discovery on Mission STS-133 made its final landing after 39 flights.